Ulex europaeus (Gorse) Lectin (UEA II) - Pure

Ulex europaeus (Gorse) Lectin (UEA II) - Pure

Regular price $119.00 Sale
SKU# 21560049-1

Product Description

Ulex europaeus agglutinin (UEA II) is isolated from gorse seeds and separated from crude extract. This lectin is a glycoprotein that consists of four 24,000 Da monomer subunits that require Ca2+ for binding to its ligands through carbohydrate recognition domain. It is specific for di-N-acetylchitobiose, an oligomer of GlcNAc. The monosaccharide GlcNAc is not an inhibitor of the lectin activity. UEA II has no mitogenic activity and agglutinates type O erythrocytes with greater interest than type A3 erythrocytes. Treatment of the lectin with EDTA abolishes agglutinating activity, although activity returns with the addition of calcium.

UEA II is a potent inhibitor of the lectin complement pathway following endothelial oxidative stress. The molecular mechanism of UEA II-induced inhibition of the lectin complement pathway appears to be through competition for a common binding site on the endothelial cell and not at the level of mannose-binding lectin (MBL) inhibition.

This product comes in a lyophilized form and is stored at -20°C. Calcium, manganese, and zinc ions are required for binding.

Technical Specifications

Molecular Weight: 96 kDa
Synonyms: UEA II
Appearance Form: White to off-white
Shelf Life: 2 years
Storage Temperature: -20°C
Hazardous Shipping: Non-hazardous