Sambucus nigra (Elderberry) Lectin (SNA/EBL II) - Pure
Sambucus nigra lectin (EBL II/SNA II) is isolated from elderberry bark. This lectin is a glycoprotein containing 7.8% carbohydrate and is not blood group specific. It is composed of two subunits and has a molecular weight of 140,000. EBL II has a specificity for carbohydrates containing terminal N-acetylgalactosamine and galactose residues.
The blood group A-active trisaccharide containing L-fucosyl group linked ?1-2 to galactose is 10-fold lesser as an inhibitor than the parent oligosaccharide (GalNAc ?1-3Gal), which suggests steric hindrance to binding by the ?-L-fucosyl group and explains the failure of the lectin to exhibit blood group A specificity.
EBL II induces caspase-dependent apoptosis at low concentrations (nM) order, leading to typical symptoms of cell death in sensitive cells. This effect seems dependent on the carbohydrate binding B-chain.
This product comes in a lyophilized form and is stored at -20°C.
|Molecular Weight||:||140 kDa|
|Shelf Life||:||2 years|