Bleomycin is a mixture of basic antineoplastic antibiotics produced by glycopeptide produced by StreptomycesÃ¥ÃŠverticullus. Bleomycin binds to DNA and causes strand breaks. Bleomycin also inhibitsÃ¥ÃŠincorporationÃ¥ÃŠthymidine into DNA strands. DNA cleavage by bleomycin depends on oxygen and metal ions, at leastÃ¥ÃŠin vitro.
Soluble in water (20 mg/ml), methanol, moderate ethanol, PBS (pH 7.2) (10 mg/mL), DMF (2 mg/mL), and DMSO (13 mg/mL).