Designed to kill fungi, this solution acts by forming channels in fungal membranes and causing the cells to become leaky. It is toxic to eukaryotic cells in culture, thus very low doses are recommended. High concentrations of amphotericin B solution (FUNGIZONE) are not recommended for routine prophylactic use.
Soluble in DMSO (30-40 mg/ml), acidic water (pH 2) or basic water (pH 11) (~0.1 mg/ml), DMF (2-4 mg/ml), DMF + 1 M HCl (3:1) (60-80 mg/ml), and methanol (slightly). Insoluble in ether.